Cellab® Bioreactor System

Protein Production with the Cellab® Bioreactor System

With the Cellab® Bioreactor System you can achieve:

Benefits for protein production

Proteins are essential in nature and take different conformations depending on their function. Today most therapeutic proteins are made using recombinant DNA technology and genetically modified cells.

The Cellab® Bioreactor System allows you to increase the efficiency of your protein production whether you opt for a manual system with our flat membrane Diaserts, or for a semi-automated system using our hollow fiber technology, scaffolds or multiple flat membrane inserts.

These easy-to-use systems provide the optimal conditions for cell cultivation.

Cellab Protein Production

Read more about the Cellab Products and their technical information

High protein concentration with minimal interventionCellab Protein Production antibody production

Producing monoclonal antibodies from different hybridoma cell lines using Cellab® Diaserts (dialysis membrane based inserts) increases the concentration of antibodies production by about 20 times compared to antibodies produced with T-Flasks or roller bottles.

Similar results are shown for hollow fiber bioreactor systems where the semipermeable membrane enables cells to be cultured at a very high density.

Despite the small housing of the bioreactor, the semipermeable membrane provides a very high surface area. In addition, the continuous circulation of nutrient and oxygen-rich media along with continuous removal of metabolites and CO2 from the cell side allows for an optimal cultivation of the cells.

The Cellab® Bioreactor System helps you to reach high density cell concentration combined with high protein concentration.

Read More about high-density culture of hybridoma cells in Diaserts

Long duration of cultivation and several harvests possible

Cellab Protein Production MAB concentrationsWhile producing monoclonal antibodies from hybridoma cells using the Cellab® hollow fiber bioreactor, the results obtained by our customers have shown that after 44 days of cell culture and 3 harvests, a total of 56.5 mg of monoclonal antibodies were harvested from a total volume of 13.9 ml.

Multiple cell lines can be maintained in the hollow fiber bioreactors for up to 3 months while a continuous harvest of protein is possible. No bioreactor replacement or transference is necessary in that period.

The Cellab® Bioreactor System provides a higher antibody concentration over a long period of time due to the high cell density.

Read More about efficient antibody production with the Cellab® Bioreactor System

Reduced media and consumables needed

One of our customers compared Cellab® Hollow Fiber Bioreactor with a T-Flask and a conventional two-compartment bioreactor system (miniPERM®). The results show the highest monoclonal antibody yield with the lowest volume of supernatant in the Cellab® Bioreactor System.

With the Cellab® Bioreactor System, reduced media and purification consumables are needed to isolate and purify the harvested antibodies. The total volume that must be processed to obtain the purified antibodies decreased tremendously. This results in lower media, purification and labor costs as well as less handling time. 

Figure 1: Total amounts of monoclonal antibodies purified from the harvests of MFP (high antibody producer) and Ata (low antibody producer) cell lines after a cultivation period of 12 days
Cellab Protein Production purified antibody
Figure 2: Volume of cell culture supernatant that has to be processed to obtain 25mg of purified monoclonal antibodies from MFP and from Ata
Cellab Protein Production cell culture supernatant

Read more about efficiency in antibody production

Parallel cultivation and reduced handling time

The Cellab® Bioreactor System allows for the cultivation of up to 24 different hybridoma cell lines while using dialysis membrane-based inserts (Diaserts), and up to 3 different hybridoma cell lines with hollow fiber bioreactors.

Parallel cultivation reduces handling time and consumables required. 

 Lower overall cost per culture

The Cellab® Bioreactor System provides a high cell density production combined with high protein concentration while lowering the overall cost of production. It enables the production of proteins with less handling (as opposed to T-Flasks which require a significant amount of manipulation for cell splitting and medium change as well as a large volume of supernatant and space for the development of the culturing process). Reducing handling and volumes also reduces the risks of contamination.

Cellab Protein Production Costs

With the Cellab® Bioreactor System, the total cost per culture is reduced by up to 60%, while at the same time offering superior control of the cell culturing and reducing purification and labor costs.

The Cellab® Bioreactor System at a glance:

  • Easy-to-use and reliable disposable bioreactor system
  • Cultivates high cell densities
  • Minimal manual intervention
  • Reduced media volume

Ordering Information

Cellab Protein Production Ordering Information

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