Biomass Production with the Cellab® Bioreactor System
With the Cellab® Bioreactor System you can achieve:
Benefits for biomass production
Demand for biomass such as Mesenchymal Stem Cells (MSC) is increasing given that these cells can be used in many different fields of research. Especially they are very promising for regenerative medicine.
The Cellab® Bioreactor System allows the production of adherent (e.g. MSCs or endothelial cells) and suspension cells (e.g. lymphocytes) with hollow fiber membrane bioreactors or scaffold holders.
This system is easy-to-use and helps increase efficiency in your cell culturing because it creates the optimal environment for the cells.
- Figure 1: Stroma-vascular fraction cells cultivated in single hollow fiber bioreactor. Cells adapted at more than twice the rate of a typical conventional static bioreactor
The cells are not disturbed by the medium flow as the cell side is separated from the medium side by a semipermeable membrane. Therefore they are not exposed to shear stress.
Additionally the tubular hollow-fiber structures provide them with an environment to grow in three-dimensional structure which better simulates in vivo conditions
The Cellab® Bioreactor System provides an environment adapted to the needs of the cells and is ideal to reach a high cell quality. It is also a modular system which grows with your required cell quantities and accompanies you in your upscaling process.
Human MSC grow well within the reactor allowing you to achieve your target number of cells and flow rates. They can be cultivated for at least 21 days in the bioreactor without affecting the multipotency of the cells.
Due to the optimal situation of the cells (excellent nutrification, gas supply and removal of metabolites), avoiding shear stress and providing in vivo-like conditions long-term cultivation of many months is possible.
The Cellab® Bioreactor System allows long-duration cell cultivation with a constant quality of the cells. The results are scalable and reproducible. This system is essential if you value both quality and quantity.
Customers were able to demonstrate cell growth inside as well as outside the hollow fibers in densities higher than in conventional suspension reactors.
The Cellab® Bioreactor System helps to reach a higher quality and a high density of cells in a shorter period of time with less handling steps as well as achieving more reproducible cell production and constant-quality results.
The Cellab® Bioreactor System at a glance:
- easy-to-use and reliable disposable bioreactor system
- cultivates high cell densities
- reduced manual interventions and medium volume
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