Cellab® Bioreactor System

Biomass Production with the Cellab® Bioreactor System

With the Cellab® Bioreactor System you can achieve:

Benefits for biomass production

Demand for biomass such as Mesenchymal Stem Cells (MSC) is increasing given that these cells can be used in many different fields of research. Especially they are very promising for regenerative medicine.

The Cellab® Bioreactor System allows the production of adherent (MSC or endothelial cells for example) and suspension cells (such as lymphocytes) with hollow fiber membrane bioreactors, scaffold holders or flat membrane inserts.

This system is easy-to-use and helps increase efficiency in your cell culturing because it creates the optimal environment for the cells.

Cellab Biomass Production

Read more about the Cellab Products and their technical information

 High efficiency rates

Cellab Biomass Production Stroma vascular fraction cellsFigure 1: Stroma-vascular fraction cells cultivated in single hollow fiber bioreactor. Cells adapted at more than twice the rate of a typical conventional static bioreactor
While using the Cellab® Bioreactor System, customers have found that cells adapted at more than twice the rate of a typical conventional static bioreactor

The cells are not disturbed by the media flow as the cell side is separated from the media side by a semipermeable membrane. Therefore they are not exposed to shear stress.

Additionally the tubular hollow-fiber structures provide them with an environment to grow in three-dimensional structure which better simulates in vivo conditions

The Cellab® Bioreactor System provides an environment adapted to the needs of the cells and is ideal to reach a high cell quality. It is also a modular system which grows with your required cell quantities and accompanies you in your upscaling process.

Long duration of cultivation

Human MSC grow well within the reactor allowing you to achieve your target number of cells and flow rates. They can be cultivated for at least 21 days in the bioreactor without affecting the multipotency of the cells.

Due to the optimal situation of the cells (excellent nutrification, gas supply and removal of metabolites), avoiding shear stress and providing in vivo-like conditions long-term cultivation of many months is possible.

The Cellab® Bioreactor System allows long-duration cell cultivation with a constant quality of the cells. The results are scalable and reproducible. This system is essential if you value both quality and quantity.

 Read more about efficient cell culturing for Mesenchymal Stem Cell applications

High density cultures

The Cellab® Bioreactor System can grow cell lines in much higher density than suspended bioreactors due to the semipermeable membrane. This semipermeable membrane provides a very high surface area despite the small housing of the bioreactor. Additionally the cells are optimally nourished by the continuous circulation of nutrient and oxygen-rich media. In parallel metabolites and CO2 are removed from the cell side.

The results obtained by our customers demonstrate that cells could be adapted to grow inside or outside of each capillary hollow fiber at densities of 10-40 times conventional suspension bioreactors and can be removed easily by using enzymes like Trypsin or Acutase.

The Cellab® Bioreactor System helps to reach a higher quality and a high density of cells in a shorter period of time with less handling steps as well as achieving more reproducible cell production and constant-quality results.

Cellab Biomass Production KeratinocytesFigure2: Development of keratinocytes (HaCaT) on inside of Cellab® hollow fiber viewed using DAPI-staining and fluorescent microscopy.

The Cellab® Bioreactor System at a glance:

  • easy-to-use and reliable disposable bioreactor system
  • cultivates high cell densities
  • minimal manual intervention
  • reduced media volume

Ordering Information

Cellab Biomass Production Ordering Information

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